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研究業績

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Journal Publications
  1. Ohira K. Localization of truncated TrkB and co-expression with full-length TrkB in the cerebral cortex of adult mice. Neuropeptides in press. メディアによる報道 >> ValuePress

  2. Ohira K. Change of hypothalamic adult neurogenesis in mice by chronic treatment of fluoxetine. BMC Research Notes 15: 60, 2022.

  3. Ohira K. Cortical adult neurogenesis and its biological implication. Clinical and Experimental Neuroimmunology 14:  44-51, 2023. Accepted manuscript PDF.

  4. Nambu Y, Ohira K, Morita M, Yasumoto H, Kurganov E, Miyata S. Effects of leptin on proliferation of astrocyte- and tanycyte-like neural stem cells in the adult mouse medulla oblongata. Neuroscience Research 173:44-53, 2021.

  5. Hagihara H, Murano T, Ohira K, Miwa M, Nakamura K, Miyakawa T. Expression of progenitor cell/immature neuron markers does not present definitive evidence for adult neurogenesis. Molecular Brain 12: 108, 2019.

  6. Ohira K*. Dopamine as a growth differentiation factor in the mammalian brain. Neural Regeneration Research 15: 390-393, 2020.

  7. Ohira K, Hagihara H, Miwa M, Nakamura K, Miyakawa T. Fluoxetine-induced dematuration of hippocampal neurons and adult cortical neurogenesis in the common marmoset. Molecular Brain 12: 69, 2019.

  8. Ohira K*. Dopamine stimulates differentiation and migration of cortical interneurons. Biochemical and Biophysical Research Communications 512: 577-583, 2019.

  9. Hagihara H, Ohira K, Miyakawa T. Transcriptomic evidence for immaturity induced by antidepressant fluoxetine in the hippocampus and prefrontal cortex. Neuropsychopharmacology Reports 39: 78-89, 2019. doi: 10.1002/npr2.12048.

  10. Ohira K*. Regulation of adult neurogenesis in the cerebral cortex. Journal of Neurology and Neuromedicine 3(4):59-64, 2018.

  11. Nakao A, Miyazaki N, Ohira K, Hagihara H, Takagi T, Usuda N, Ishii S, Murata K, Miyokawa T. Immature morphological properties in sub cellular-scale structures in the dentate gyrus of Schnurri-1 knockout mice: a model for schizophrenia and intellectual disability. Molecular Brain 10: 60, 2017.

  12. Okada Y, Ohira K*. Population dynamics of neural progenitor cells during aging in the cerebral cortex. Biochemical and Biophysical Research Communications 493: 182-187, 2017. セルフレポジトリ(accepted version) メディアによる報道 >>PR today, ValuePress, 認知症ねっと

  13. Mizui T, Ohira K, Kojima M. BDNF pro-peptide: a novel synaptic modulator generated as an N-terminal fragment from the BDNF precursor by proteolytic processing. Neural Regeneration Research 12: 1024-1027, 2017.

  14. Akers KG, Martinez-Canabal A, Restivo L, Yiu AP, De Cristofaro A, Hsiang HL, Wheeler AL, Guskjolen A, Niibori Y, Shoji H, Ohira K, Richards BA, Miyakawa T, Josselyn SA, Frankland PW. Hippocampal neurogenesis regulates forgetting during adulthood and infancy. Science 344: 598-602, 2014.

  15. Hagihara H, Ohira K, Takao K, Miyakawa T. Transcriptomic evidence for immaturity of the prefrontal cortex in patients with schizophrenia. Molecular Brain 7: 41, 2014.

  16. Hattori S, Hagihara H, Ohira K, Aoki I, Saga T, Suhara T, Higuchi M, Miyakawa T. In vivo evaluation of cellular activity in αCaMKII heterozygous knockout mice using manganese-enhanced magnetic resonance imaging (MEMRI). Frontiers in Integrative Neuroscience 7: 76, 2013.

  17. Ohira K*, Takeuchi R, Iwanaga T, Miyakawa T*. Chronic fluoxetine treatment reduces parvalbumin expression and perineuronal nets in gamma-aminobutyric acidergic interneurons of the frontal cortex in adult mice. Molecular Brain 6: 43, 2013. >>EurekAlert!

  18. Takao K, Kobayashi K, Hagihara H, Ohira K, Shoji H, Hattori S, Koshimizu H, Umemori J, Toyama K, Nakamura HK, Kuroiwa M, Maeda J, Atsuzawa K, Esaki K, Yamaguchi S, Furuya S, Takagi T, Walton NM, Hayashi N, Suzuki H, Higuchi M, Usuda N, Suhara T, Nishi A, Matsumoto M, Ishii S, Miyakawa T. Deficiency of schnurri-2, an MHC enhancer binding protein, induces mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia. Neuropsychopharmacology 38: 1409-1425, 2013.

  19. Ohira K*, Takeuchi R, Shoji H, Miyakawa T*. Fluoxetine-induced cortical adult neurogenesis. Neuropsychopharmacology 38: 909-920, 2013. >>JST press release

  20. Ohira K, Kobayashi K, Toyama K, Nakamura HK, Shoji H, Takao K, Takeuchi R, Yamaguchi S, Kataoka M, Otsuka S, Takahashi M, Miyakawa T. Synaptosomal-associated protein 25 mutation induces immaturity of the dentate granule cells of adult mice. Molecular Brain 6: 12, 2013.

  21. Ohira K, Miyakawa T. Chronic treatment with fluoxetine for more than 6 weeks decreases neurogenesis in the subventricular zone of adult mice. Molecular Brain 4: 10, 2011.

  22. Hagihara H, Ohira K, Toyama K, Miyakawa T. Expression of the AMPA Receptor Subunits GluR1 and GluR2 is Associated with Granule Cell Maturation in the Dentate Gyrus. Frontiers in Neuroscience 5: 100, 2011.

  23. Koshimizu H, Fukui Y, Takao K, Ohira K, Tanda K, Nakanishi K, Toyama K, Oshima M, Taketo MM, Miyakawa T. Adenomatous polyposis coli heterozygous knockout mice display hypoactivity and age-dependent working memory deficits. Frontiers in Behavioral Neuroscience 5: 85, 2011.

  24. Ohira K. Injury-induced neurogenesis in the mammalian forebrain. Cellular and Molecular Life Sciences 68: 1645-1656, 2011.

  25. Ohira K, Hagihara H, Toyama K, Takao K, Kanai M, Funakoshi H, Nakamura T, Miyakawa T. Expression of tryptophan 2,3-dioxygenase in mature granule cells of the adult mouse dentate gyrus. Molecular Brain 3: 26, 2010.

  26. Ohira K*, Kaneko T*. Injection of virus vectors into the neocortical layer 1. Nature Protocol Exchange doi:10.1038/nprot.2010.21, 2010.

  27. Ohira K*, Furuta T, Hioki H, Nakamura KC, Kuramoto E, Tanaka Y, Funatsu N, Shimizu K, Oishi T, Hayashi M, Miyakawa T, Kaneko T*, Nakamura S. Ischemia-induced neurogenesis of neocortical layer 1 progenitor cells. Nature Neuroscience 13: 173-179, 2010. >>JST press release

  28. Matsuo N, Yamasaki N, Ohira K, Takao K, Toyama K, Eguchi M, Yamaguchi S, Miyakawa T. Neural activity changes underlying the working memory deficit in alpha-CaMKII heterozygous knockout mice. Frontiers in Behavioral Neuroscience 3: 20, 2009.

  29. Ohira K, Hayashi M. A New aspect of the TrkB signaling pathway in neural plasticity. Current Neuropharmacology 7: 276-285, 2009.

  30. Yamasaki N, Maekawa M, Kobayashi K, Kajii Y, Maeda J, Soma M, Takao K, Tanda K, Ohira K, Toyama K, Kanzaki K, Fukunaga K, Sudo Y, Ichinose H, Ikeda M, Iwata N, Ozaki N, Suzuki H, Higuchi M, Suhara T, Yuasa S, Miyakawa T. Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders. Molecular Brain 1: 6, 2008.

  31. Kameda H, Furuta T, Matsuda W, Ohira K, Nakamura K, Hioki H, Kaneko T. Targeting green fluorescent protein to dendritic membrane in central neurons. Neuroscience Research 61: 79-91, 2008.

  32. Hioki H, Kameda H, Nakamura H, Okunomiya T, Ohira K, Nakamura K, Kuroda M, Furuta T, Kaneko T. Efficient gene transduction of neurons by lentivirus with enhanced neuron-specific promoters. Gene Therapy 14: 872-882, 2007.

  33. Ohira K, Funatsu N, Homma KJ, Sahara Y, Hayashi M, Kaneko T, Nakamura S. Truncated TrkB-T1 regulates the morphology of neocortical layer I astrocytes in adult rat brain slices. European Journal of Neuroscience 25: 406-416, 2007.

  34. Ohira K, Homma KJ, Hirai H, Nakamura S, Hayashi M. TrkB-T1 regulates the RhoA signaling and actin cytoskeleton in glioma cells. Biochemical and Biophysical Research Communications 342: 867-874, 2006.

  35. Ohira K, Shimizu K, Yamashita A, Hayashi M. Differential expression of the truncated TrkB receptor, T1, in the primary motor and prefrontal cortices of the adult macaque monkey. Neuroscience Letters 385: 105-109, 2005.

  36. Ohira K, Kumanogoh H, Sahara Y, Homma KJ, Hirai H, Nakamura S, Hayashi M. A truncated tropomyosin-related kinase B receptor, T1, regulates glial cell morphology via Rho GDP dissociation inhibitor 1. Journal of Neuroscience 25: 1343-1353, 2005.

  37. Ohira K, Funatsu N, Nakamura S, Hayashi M. Expression of BDNF and TrkB receptor subtypes in the postnatal developing Purkinje cells of monkey cerebellum. Gene Expression Patterns 4: 257-261, 2004.

  38. Ohira K, Hayashi M. Expression of TrkB subtypes in the adult monkey cerebellar cortex. Journal of Chemical Neuroanatomy 25: 175-183, 2003.

  39. Hayashi M, Mistunaga F, Ohira K, Shimizu K. Changes in BDNF-immunoreactive structures in the hippocampal formation of the aged macaque monkey. Brain Research 918: 191-196, 2001.

  40. Ohira K, Shimizu K, Hayashi M. TrkB dimerization during development of the prefrontal cortex of the macaque. Journal of Neuroscience Research 65: 463-469, 2001.

  41. Ohira K, Maekawa S, Hayashi M. Absence of TrkB and insulin receptor beta in the Triton insoluble low-density fraction (raft). NeuroReport 11: 1307-1311, 2000.

  42. Hayashi M, Mitsunaga F, Ohira K, Shimizu K, Yamashita A. Development of full-length Trk B-immunoreactive structures in the hippocampal formation of the macaque monkey. Anatomy and Embryology 199: 529-537, 1999.

  43. Ohira K, Shimizu K, Hayashi M. Change of expression of full-length and truncated TrkBs in the developing monkey central nervous system. Developmental Brain Research 112: 21-29, 1999. 

"I love fools’ experiments.

I am always making them."

-  Charles Darwin  -

Academic Publications 
  1. 大平耕司. 脳疾患に対する大脳皮質成体神経新生の利用可能性. 細胞 56 (8), pp 71-73, 2024. ニューサイエンス.

  2. 大平耕司. 脳疾患に対する予防・治療法に向けた基礎研究:大脳皮質の成体神経新生を活用した方法. 細胞 54 (7), pp 45-47, 2022. ニューサイエンス.

  3. 大平耕司. 大脳皮質の成体神経新生と脳疾患. アグリバイオ 6 (1), pp 40-43, 2022. 北隆館.

  4. Ohira K.* Neural progenitor cells in the cerebral cortex of adult humans, and its relationship to neuropsychiatric disorders. Impact, Volume 2019, Number 6, June 2019, pp. 94-96(3). Download PDF. Impact は、世界中の大学、政策、政府、民間、公共セクター、研究機関、国と地域の研究資金補助組織など主要な関係者に読まれる英国の雑誌です。

  5. 大平耕司、小島正己. 現場の声5 研究を社会へ拡げる動物実験. 太田信夫監修、片山順一編集. シリーズ心理学と仕事 神経•生理心理学. 北大路書房, pp 72-73, 2019.

  6. Ohira K*. Neocortical Adult Neurogenesis during Aging. In: Strakos R, Lorena B (eds). New Research on Cell Aging and Death. NOVA Science Publishers: New York, pp 109-130, 2018.

  7. 大平耕司. 神経再生. 橋本信夫(監修), 三國信啓, 深谷親(編集). 脳神経外科医が知っておくべきニューロサイエンスの知識. 文光堂, pp 40-41, 2015.

  8. Ohira K*. Fluoxetine and its novel effect on adult neurogenesis. In: Pinna G (ed). Fluoxetine: Pharmacology, Mechanisms of Action and Potential Side Effects. NOVA Science Publishers: New York, pp 97-106, 2015.

  9. Ohira K*. Neurogenesis in the adult neocortex under pathological conditions. In: Clark GJ, Anderson WT (eds). Neurogenesis Research: New Developments. NOVA Science Publishers: New York, pp 161-176, 2012.

  10. 大平耕司、宮川剛. 大脳皮質の新しい前駆細胞. Clinical Neuroscience 29: 1434-1435, 2011.

  11. 林基治、大平耕司. 脳の発達と神経栄養因子. Brain Medical 11(3): 281-286, 1999.

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